The comparison of attenuation factor of 99mTc and 153Sm radionuclides in planar image using Mediso InterViewTM XP and ImageJ

Abstract

Planar imaging quantification is a method in internal dosimetry studies that is needed in the preparation and post-therapy evaluation stages. The attenuation factors are needed in Conjugate View Method to obtain accurate image quantification results. In nuclear medicine installation, the high workload of integrated software slows the quantification process, so it is necessary to advance alternative software that is portable and has high accuracy. This study aims to compare the result of attenuation factors using InterView^TM XP and ImageJ plug-in software. The study was conducted by observing attenuation of ^99mTc and ¹⁵³Sm, which have 1, 2, 4, and 25 mCi activities on water slabs phantom with thickness variations of 1–10 cm using a Mediso Anyscan S equipped with Low-Energy High-Resolution collimator. Radionuclides activity measurement was performed using a dose calibrator. The energy window of each radionuclide is adjusted to the spectrum range in the gamma camera software. Image quantification was executed with InterView^TM XP and ImageJ plug-in software. The attenuation factor is obtained by plotting a graph between count versus slab thickness. Analysis result using InterView^TM XP and ImageJ software sequentially is 0.140 ± 0.007 cm^-1, 0.140 ± 0.009 cm^-1 (^99mTc), and 0.128 ± 0.004 cm^-1, 0.128 ± 0.004 cm^-1 (¹⁵³Sm) at activity range 1–25 mCi. The result of Paired Samples t-test between ImageJ towards integrated InterView^TM XP software shows that the value of Significance (2-tail) > α; thus, H₀ is accepted. It is concluded that ImageJ software is quite accurate in determining the value of attenuation factors.