Virtual study to investigate the detectability of breast abnormalities on 2D mammography and digital breast tomosynthesis

Kristina Tri Wigati, Hannah Manssens, Liesbeth Vancoillie, Cockmartin Lesley, Djarwani Soeharso Soejoko, Hilde Bosmans, Kristina Bliznakova

Abstract


This paper describes the use of virtual clinical trial software, as developed and improved in the frame of the Horizon2020 MaXIMA project, to study particular aspects of 2D mammography and digital breast tomosynthesis. A voxel-based breast phantom with inserted mathematical models of an irregular mass and two microcalcifications was created. Image acquisition was simulated by using XRAYImagingSimulator, while image reconstruction was accomplished with FDKR software. Series of images were created for different angular ranges with an identical total dose. Detectability of the abnormalities was investigated using visual assessment and quantitative measurements. The results agree with other studies in literature studying the same aspects and therefore confirm the value of the new framework for other future applications.


Full Text:

PDF

References


L. Cockmartin, N.W. Marshall, C. Van Ongeval, G. Aerts, D. Stalmans, F. Zanca, E. Shaheen, F. De Keyzer, D.R. Dance, K.C. Young, and H. Bosmans, "Comparison of digital breast tomosynthesis and 2D digital mammography using a hybrid performance test," Phys. Med. Biol. 60, 3939–3958 (2015).

E. Shaheen, C. Van Ongeval, F. De Keyzer, D.R. Dance, K.C. Young, and H. Bosmans, "The simulation of 3D mass models in 2D digital mammography and breast tomosynthesis," Med. Phys. 41(8), 081913 1–17 (2014).

E. Shaheen, C. Van Ongeval, F. Zanca, L. Cockmartin, N. Marshall, J. Jacobs, K.C. Young, D.R. Dance, and H. Bosmans, "The simulation of 3D microcalcification cluster in 2D digital mammography and breast tomosynthesis," Med. Phys. 38(12), 6659–6671 (2011).

Y. Baneva, K. Bliznakova, L. Cockmartin, S. Marinov, I. Buliev, G. Mettivier, H. Bosmans, P. Russo, N. Marshall, and Z. Bliznakov, "Evaluation of a breast software model for 2D and 3D X-ray imaging studies of the breast," Phys. Med. (2017)

X.G. Xu, "An exponential growth of computational phantom research in radiation protection, imaging, and radiotheraphy: a review of the fifty-year history," Phys. Med. Biol. 59, R233–R302 (2014).

L. Cockmartin, N.W. Marshall, G. Zhang, K. Lemmens, E. Shaheen, C. Van Ongeval, E. Fredenberg, D. R. Dance, E. Salvagnini, K. Michielsen, and H. Bosmans, "Design and application of a structured phantom for detection performance comparison between breast tomosynthesis and digital mammography," Phys. Med. Biol. 62, 758–780 (2017).

A. Taibi, S. Fabbri, P. Baldelli, C. di Maggio, G. Gennaro, M. Marziani, A. Tuffanelli, and M. Gambaccini, "Dual-energy imaging in full-field digital mammography: a phantom study," Phys. Med. Biol. 48, 1945–1956 (2003).

L.C. Ikejimba, S. J. Glick, K.R. Choudhury, E. Samei, and J.Y. Lo, "Assessing task performance in FFDM, DBT, and synthetic mammography using uniform and anthropomorphic physical phantoms," Med. Phys. 43(10), 5593–5602 (2016).

L. Cockmartin, H. Bosmans, and N.W. Marshall, "Comparative power law analysis of structured breast phantom and patient images in digital mammography and breast tomosynthesis," Med. Phys. 40(8), 081920 1–17 (2013).

H. Zaidi and B.M.W. Tsui, "Review of computational anthropomorphic anatomical and physiological models," Proceedings of the IEEE 97(12), 1938–1953 (2009).

D.D. Pokrajac, A.D.A. Maidment, and P.R. Bakic, "Optimized generation of high resolution breast anthropomorphic software phantoms," Med. Phys. 39(4), 2290–2302 (2012).

N. Kiarashi, A.C. Nolte, G.M. Sturgeon, W.P. Segars, S.V. Ghate, L.W. Nolte, and E. Samei, "Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data," Med. Phys. 42(7), 4116–4126 (2015).

A.K. Carton, P. Bakic, C. Ullberg, H. Derand, and A.D.A. Maidment, "Development of a physical 3D anthropomorphic breast4

C.M. Li, W.P. Segars, G.D. Tourassi, J.M. Boone, and J.T. Dobbins III, "Methodology for generating a 3D computerized breast phantom from empirical data," Med. Phys. 36(7), 3122–3131 (2009).

K. Bliznakova, Z. Bliznakov, V. Bravou, Z. Kolitsi, and N. Pallikarakis, "A three-dimensional breast software phantom for mammography simulation," Phys. Med. Biol. 48, 3699–3719 (2003).

K. Bliznakova, S. Kazakli, and N. Pallikarakis, "An optimised 3D breast phantom for X-ray breast imaging techniques," IFMBE Proceedings 22, 2455–2458 (2008).

K. Bliznakova, S. Suryanarayanan, A. Karellas, and N. Pallikarakis, "Evaluation of an improved algorithm for producing realistic 3D breast software phantoms: application for mammography," Med. Phys. 37(11), 5604–5617 (2010).

P.R. Bakic, M. Albert, D. Brzakovic, and A.D.A. Maidment, "Mammogram synthesis using a 3D simulation. I. Breast tissue model and image acquisition simulation," Med. Phys. 29(9), 2131–2139 (2002).

P.R. Bakic, M. Albert, D. Brzakovic, and A.D.A. Maidment, "Mammogram synthesis using a 3D simulation. II. Evaluation of synthetic mammogram texture," Med. Phys. 29(9), 2140–2151 (2002).

P.R. Bakic, M. Albert, D. Brzakovic, and A.D.A. Maidment, "Mammogram synthesis using a 3D simulation. III. Modelling and evaluation of the breast ductal network," Med. Phys. 30(7), 1914–1925 (2003).

B. Chen, J. Shorey, R.S. Saunders, S. Richard, J. Thompson, L.W. Nolte, and E. Samei, "An anthropomorphic breast model for breast imaging simulation and optimization," Acad. Radiol. 18, 536–546 (2011).

I. Sechopoulos, "A review of breast tomosynthesis. Part I. The image acquisition process," Med. Phys. 40(1), 014301 1–12 (2013).

I. Sechopoulos, "A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications," Med. Phys. 40(1), 014302 1–17 (2013).

D. R. Dance, S. Christofides, A. D. A. Maidment, I. D. McLean, and K. H. Ng, "Diagnostic Radiology Physics: A handbook for teachers and students," IAEA (2014).

X. Yang, I. Sechopoulos, and B. Fei, “Automatic tissue classification breast CT images based on bilateral filtering,” Proc. SPIE 7962: 79623H (2011).

K. Bliznakova, R. Speller, J. Horrocks, P. Liaparinos, Z. Kolitsi, N. Pallikarakis, “Experimental validation of a radiographic simulation code using breast phantom for x-ray imaging,” Comput. Biol. Med. 40, 208–214 (2014).

H. Hintsala, K. Bliznakova, N. Pallikarakis, and T. Jämsä, “Modelling of Irregular Breast Lesions,” IFMBE Proc. 25(IV), 2024–2027 (2009).

D. Lazos, Z. Kolitsi, and N. Pallikarakis, "A software data generator for radiographic imaging investigations," IEEE Trans. Inf. Technol. Biomed. 4(1), 76–79 (2000).

L.A. Feldkamp, L.C. Davis, and J.W. Kress, "Parctical cone-beam algorithm," J. Opt. Soc. Am. 1(6), 612–619 (1984).

C. Zyganitidis, K. Bliznakova, and N. Pallikarakis, "A novel simulation algorithm for soft tissue compression," Med. Bio. Eng. Comput. 45: 661–669 (2007).


Refbacks

  • There are currently no refbacks.


©2017 (onwards) Aliansi Fisikawan Medik Indonesia / Indonesian Association of Physicists in Medicine

Print ISSN: 2355-2727 | Online ISSN: 2355-2719